Nicholas T Seyfried Selected Research

Detergents (Detergent)

1/2021	Targeted Quantification of Detergent-Insoluble RNA-Binding Proteins in Human Brain Reveals Stage and Disease Specific Co-aggregation in Alzheimer's Disease.
1/2018	Characterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy.
10/2017	Enrichment of Detergent-insoluble Protein Aggregates from Human Postmortem Brain.
12/2016	Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression.
5/2012	Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards.
11/2011	Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration.

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Nicholas T Seyfried Research Topics

Disease

53	Alzheimer Disease (Alzheimer's Disease) 05/2022 - 02/2011
15	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 11/2011
15	Cognitive Dysfunction 01/2022 - 12/2013
9	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2022 - 04/2010
8	Neuroinflammatory Diseases 07/2022 - 01/2017
8	Inflammation (Inflammations) 01/2022 - 01/2017
8	Neoplasms (Cancer) 01/2022 - 05/2008
7	Dementia (Dementias) 01/2022 - 02/2016
6	Parkinson Disease (Parkinson's Disease) 01/2021 - 10/2013
5	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022 - 04/2010
5	Tauopathies 01/2022 - 01/2020
5	Frontotemporal Dementia (Semantic Dementia) 01/2021 - 01/2018
5	Disease Progression 01/2020 - 12/2010
3	Proteostasis Deficiencies 07/2022 - 10/2017
2	Synucleinopathies 01/2022 - 08/2017
2	Hippocampal Sclerosis 01/2022 - 11/2020
2	Amyloidosis 01/2022 - 10/2014
2	Down Syndrome (Down's Syndrome) 01/2022 - 04/2014
2	Infarction (Infarctions) 01/2022 - 11/2020
2	Intracranial Arteriosclerosis (Cerebral Atherosclerosis) 01/2021 - 01/2020
2	Chronic Traumatic Encephalopathy 01/2021 - 01/2018
2	Hypoxia (Hypoxemia) 01/2017 - 07/2012
2	Ataxia Telangiectasia (Louis Bar Syndrome) 02/2016 - 08/2013
2	TDP-43 Proteinopathies 01/2012 - 04/2010
1	Parkinsonian Disorders (Parkinsonism) 05/2022
1	Vascular Diseases (Vascular Disease) 01/2022
1	Sarcoma (Soft Tissue Sarcoma) 01/2022
1	Brain Diseases (Brain Disorder) 01/2022
1	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2022
1	limbic-predominant age-related TDP-43 encephalopathy 01/2022
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2022
1	Atherosclerosis 01/2022
1	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2022
1	Colorectal Neoplasms (Colorectal Cancer) 01/2022
1	Arteriolosclerosis 01/2022
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 11/2021
1	Virus Diseases (Viral Diseases) 11/2021
1	Atrophy 01/2021
1	Craniocerebral Trauma (Head Injury) 01/2021
1	Cardiomyopathies (Cardiomyopathy) 01/2021

Drug/Important Bio-Agent (IBA)

50	Proteins (Proteins, Gene)FDA Link 05/2022 - 05/2008
18	ProteomeIBA 01/2022 - 04/2012
12	Biomarkers (Surrogate Marker)IBA 01/2022 - 05/2008
11	RNA (Ribonucleic Acid)IBA 01/2022 - 05/2012
11	Amyloid (Amyloid Fibrils)IBA 01/2021 - 10/2013
7	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2022 - 04/2010
6	UbiquitinIBA 11/2021 - 04/2010
6	Detergents (Detergent)IBA 01/2021 - 11/2011
6	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2021 - 01/2012
5	Amyloid beta-PeptidesIBA 07/2022 - 12/2016
5	Peptides (Polypeptides)IBA 01/2022 - 12/2010
5	Phosphotransferases (Kinase)IBA 01/2021 - 12/2010
4	Pharmaceutical PreparationsIBA 01/2022 - 01/2018
4	Protein AggregatesIBA 10/2018 - 10/2013
4	U1 Small Nuclear RibonucleoproteinIBA 01/2018 - 10/2013
3	Sirtuin 2IBA 01/2022 - 08/2013
3	Biological ProductsIBA 01/2021 - 01/2019
3	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 07/2012
3	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 12/2010
3	sarkosylIBA 10/2017 - 12/2014
3	asparaginylendopeptidase (legumain)IBA 08/2017 - 11/2014
2	CholesterolIBA 07/2022 - 01/2019
2	Apolipoproteins E (ApoE)IBA 01/2022 - 01/2018
2	Messenger RNA (mRNA)IBA 01/2022 - 01/2020
2	InterferonsIBA 11/2021 - 05/2008
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2021 - 12/2010
2	Potassium Channels (Potassium Channel)IBA 01/2021 - 01/2017
2	Carrier Proteins (Binding Protein)IBA 01/2019 - 01/2018
2	IsotopesIBA 01/2019 - 05/2012
2	Small Nuclear Ribonucleoproteins (snRNP)IBA 12/2014 - 04/2014
2	Nuclear Proteins (Protein, Nuclear)IBA 07/2013 - 08/2012
2	Membrane Proteins (Integral Membrane Proteins)IBA 01/2013 - 05/2008
2	PolyubiquitinIBA 03/2011 - 04/2010
1	Neurotransmitter Agents (Neurotransmitter)IBA 07/2022
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 05/2022
1	CytokinesIBA 01/2022
1	CarbonIBA 01/2022
1	CalciumIBA 01/2022
1	Serine (L-Serine)FDA Link 01/2022
1	Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)IBA 01/2022
1	OsteoprotegerinIBA 01/2022
1	Leucine (L-Leucine)FDA Link 01/2022
1	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2022
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2022
1	NAD (NADH)IBA 01/2022
1	AutoantigensIBA 01/2022
1	Atomoxetine Hydrochloride (Strattera)FDA LinkGeneric 01/2022
1	Proline (L-Proline)FDA Link 01/2022
1	diazonaphthalenedisulfonic acid (NDS)IBA 01/2022
1	RNA-Binding Protein FUSIBA 01/2022
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 06/2021
1	Mitogen-Activated Protein KinasesIBA 06/2021
1	ManganeseIBA 01/2021
1	Bile Acids and Salts (Bile Acids)IBA 01/2021
1	Phosphates (Orthophosphate)IBA 01/2021
1	OxylipinsIBA 01/2021
1	LipidsIBA 01/2021
1	SteroidsIBA 01/2021
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2021

Therapy/Procedure

5	Therapeutics 01/2022 - 10/2020